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Ibuzatrelvir is a small molecule commercialized by , with a leading Phase II program in Coronavirus Disease 2019 (COVID-19). According to Globaldata, it is involved in 7 clinical trials, of which 5 were completed, 1 is ongoing, and 1 is planned. Smarter leaders trust GlobalData The gold standard of business intelligence. The revenue for Ibuzatrelvir is expected to reach an annual total of $21 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress. Ibuzatrelvir Overview Pfizer Overview discovers, develops, manufactures, and commercializes biopharmaceuticals. The company offers products to treat various conditions such as cardiovascular, metabolic and pain, women’s health, cancer, inflammation, immune disorders, and rare diseases. It also provides sterile injectable pharmaceuticals, biosimilars, active pharmaceutical ingredients (APIs) and contract manufacturing services. sells its products through wholesalers, retailers, hospitals, individual provider offices, clinics, government agencies, and pharmacies. It has major manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US. The company provides its products in North America, South America, Asia-Pacific, Australia, Europe, Africa, and the Middle East. is headquartered in New York, the US. The company reported revenues of (US Dollars) US$58,496 million for the fiscal year ended December 2023 (FY2023), a decrease of 41.7% over FY2022. The operating loss of the company was US$929 million in FY2023, compared to an operating profit of US$36,237 million in FY2022. In FY2023, the company recorded a net margin of 3.6%, compared to a net margin of 31.3% in FY2022. The company reported revenues of US$13,283 million for the second quarter ended June 2024, a decrease of 10.7% over the previous quarter. For a complete picture of Ibuzatrelvir’s valuation, From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company. The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s .
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This is the time of year when mail can still be a pleasure. For once, you’re not asking yourself, “What did I do to deserve this junk?” as you transfer postal offerings from the front door to the recycling bin. It is the time when actual hand-addressed envelopes, which technology has so far failed to credibly replicate, can be expected to arrive. Most contain the usual mass-produced offerings, but often inscribed with special messages. Even better, many of these envelopes carry family photos of relatives you only see in person at weddings or funerals. Finally, and most intriguing, there are long-form personal communications in the form of traditional holiday letters. I have to admit I have never sent one of these, though I’m tempted by the challenge. Some have honed it to an art form. Writer Laura McTaggert, who blogs for WBUR, Boston’s public radio station, says that even though “I’ll bring a bag of chips to a potluck" and "my go-to makeup for a fancy event is ChapStick,” she “feels compelled to write a letter that is informative, entertaining and clever.” People tell McTaggert that they open her letters with anticipation, even excitement. And really, what better way for a writer to spread joy? Not only does it put a personal skill to use, there are no boxes, no wrapping, no unwanted gadgets and no needless expense. For a really funny writer’s take on the tradition, check out Catherine LeClair’s “My Mother’s Annual Holiday Letter is Spreading Fake News,” which Google will locate on the McSweeny’s website. But a letter doesn’t have to rise to high comedic excellence to be entertaining, informative or even heartwarming. Longtime practitioners of the art can be found here in Buffalo, and many friends tell me that they get letters that are among the highlights of their seasons. A former Buffalo Spree colleague, Marianne Minbiole, who now works for the Roswell Park Alliance Foundation, loves letters from her aunt and uncle, who send theirs out on Thanksgiving. She says, “They are very impressive people and included their annual roundup as they turn 80 – about their travels, their volunteer work and my uncle’s wooden toys. He donated over 1000 of them this year.” Marianne Minbiole holds holiday letters and cards she’s received and held onto over the years. Minbiole, who's 40, says she thinks it’s time for her to start her own letter tradition, explaining, “I think it would be a good opportunity to share some updates that are pretty personal. There are things I don’t want to send out to the whole Facebook world, which has gotten to be such a huge network and there are all sorts of acquaintances who don’t need to know so much.” She also feels it evokes a slower, more relaxed time: “I think it definitely follows the trend of returning to a more analog existence. I have always liked to sit and read something that is in my hands.” John B. Licata, New York State Supreme Court justice, Eighth District, demonstrates a sense of humor in his family’s annual rhyming letter that may not always be on display in his courtroom. In 2020, before Licata was elected judge, his poetic offering contained these stanzas: “By Executive orders we're limited ten to a room Our extended family parties are now done via Zoom ... John works at a great firm whose success isn't by chance He's learned Covid court appearances don't require pants? Amy is staying home, but of filled concerts she's dreaming Instead of the hall, her venue is streaming She and Teresa spend days watching Great British Baking Show Our waistlines are proving all the new things they now know” You get the idea. (Licata is not a relative, by the way.) There are other ways to make holiday communications personal. I’m lucky enough to know someone who takes the trouble to create his own annual greeting from scratch, local art collector and collage artist Gerald Mead. But if you want to get on his Christmas card list, be careful what you wish for, because someone will have to die before that can happen. Mead sends a limited edition of 10 handmade cards annually to a set list of recipients – mainly people he knows through the local art scene. Another, different set of cards goes to his family members. Both sets use found materials that might not seem like the things holiday dreams are made of: matches, cardboard slide mounts, paint samples and even, in 2020, a blue face mask folded into a Christmas tree. Artist Gerald Mead sits in his home with a selection of his limited-edition holiday cards. Mead, who’s 62, traces the tradition to his mother, the late Margaret “Betty” Mead, also an artist. “She always taught us that making a gift was much more personal and meaningful,” he says. “I would always make her handmade cards for Mother's Day and birthdays. Then I made cards as an undergraduate, using carved rubber stamp cards and I actually had them in a show at New York’s Book Arts Center, in the mid-'80s. "And so I think that kind of evolved into these cards, which I started in 1991 and are really a simpler version of my ongoing collage and assemblage work – I'm using found objects and found materials. I’m also always looking for something that's kind of ironic or has a double meaning.” Artist Gerald Mead holds one of his limited-edition holiday cards, featuring a mask cut into the shape of a tree. This year’s creation has a cut-out green banana attached to the card with a strip of red tape. Simple, but a nice conceptual twist. Mead collects possible ideas for the annual card throughout the year. Sometimes, the materials he needs aren’t so easy to pull together: “I did one that was a gift card for the Dollar Tree for $1. I go in there and I said, I just need to get 10 cards with just $1 on each one. And they said, well, it's $5 minimum. But I told them what I was doing, and they just gave me 10 with no value. So, yeah, I'm struck by things that are commonplace, but you can reframe them in a holiday context.” An artist who died in 2021, Paul Kalinowski – most knew him as Kalo – was renowned for his meticulously drawn, deliciously bizarre takes on Christmas themes. One, “Three Kings,” featured the faces of Elvis, King Tut and King Kong. Another showed Santa tied to a table by his elves, who stand laughing by as a sharp pendulum swings overhead. Paul Kalinowski's "Christmas Memories," from 1992. They weren’t cards meant for those overly serious about the traditional Christmas message. I miss those cards and have better memories of those and other artful communications from creative friends than most of the gifts I’ve received throughout the years. I’ve also kept them longer and display many of them every year at this time. Like Minbiole rereading her family letters, I enjoy each yearly encounter with Mead's visual puns and Kalinowski's twisted humor. Meaningful, DIY communication or immersion in a consumerist frenzy? For most of us, there's no contest. Get local news delivered to your inbox! 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